Endocrine Abstracts

IntroductionOncocytic neoplasms arising in adrenal tissue are extremely rare with nearly 150 cases being reported in literature. They are mostly nonfunctioning benign tumors, incidentally discovered, but 20% of them demonstrate elements of malignancy and up to 30% appear to affect hormone production.Case reportA 35 years old female with primary amenorrhea, diagnosed with Congenital Adrenal Hyperplasia due to ...

IntroductionProlactinomas are the most common hormone-secreting pituitary tumours encountered in the clinic. They are usually treated with dopamine agonists (DA): bromocriptine (BRC) and cabergoline (CAB), which are highly effective in the majority of cases. DA resistance is the failure to achieve normal levels of prolactin and, or reduction of the adenoma with at least 50%.Aimto assess the prevalence of the ...

IntroductionPituitary apoplexy is a rare entity characterized by abrupt hemorrhage and/or ischaemia of the constituents of sella turcica. It usually occurs in a previously unsuspected pituitary tumor. It may have an acute or subclinical presentation and it may represent a neuroendocrinological emergency.AimThis study aims to analyze predisposing or precipitating factors, clinical status, imaging and hormonal ...

BackgroundAcromegaly is a rare disease, caused by an autonomous excessive secretion of growth hormone (GH). Apart from skeletal alterations, the GH excess leads to metabolic and visceral disease. Thus, one of the most frequent associated complications is the cardio-vascular one represented by hypertension, cardiomyopathy and ischemic heart disease. The presence of multiple complications in patients with acromegaly leads not only to increased morbidity an...

IntroductionLung Neuroendocrine tumors (NETs) range in aggressiveness from low-grade typical carcinoid (TC) and intermediate-grade atypical carcinoid (AC) to the high-grade large cell neuroendocrine carcinoma (LCNEC) and small cell lung carcinoma (SCLC). TC have excellent prognosis post-surgery and European Neuroendocrine Tumor Society (ENETS) recommands no adjuvant therapy for these well diferentiated tumors.Case report<p clas...

Introduction: Folliculo-stellate cells (FSCs), non-endocrine star-like shaped population of cells located in the anterior pituitary, have very heterogenous function and phenotype. Located between the secretory cells, their first atributed role was connected to a supporting network. In literature, they were mentioned to be involved in the pathogenesis and evolution of pituitary neuroendocrine tumors (PitNETs).Objectives: Analyse FSCs characteristics and d...

Background: Prevalence of neuroendocrine neoplasms is increasing and multidisciplinary approach is mandatory. This study aimed to assess the outcome of patients with gastroenteropancreatic neoplasms (GEP NEN) presenting in a tertiary endocrine center.Methods: Retrospective study on 36 patients (16 M/20 F) with pathology confirmed GEP NEN, aged 51.9 &pm; 12.7 years. Serum chromogranin A, serotonin, neuron-specific enolase...

Background and objective: The purpose of this study was to retrospectively analyse the clinical, imaging and hormonal features, as well as the therapeutic outcomes in a series of consecutive patients presenting with pituitary apoplexy (PA).Design: We retrospectively reviewed 71 case-records of patients with PA admitted during 2019 in a single tertiary endocrinology center.Results: ...

Introduction: The basis of treatment of primary hyperparathyroidism (pHPT) is parathyroidectomy of the responsible lesion, and thus, preoperative localization is important. Ectopic parathyroid adenomas are rare, and they can be accounted for persistent or recurrent hyperparathyroidism. An intrathyroidal parathyroid adenoma (IPA) is an ectopic variant where the adenoma is either partly (>50%) or completely enveloped by the thyroid gland. The incidence of IPAs ranges from 0....

Introduction: Bilateral adrenal tumors in patients with adrenal Cushing’s syndrome (CS) are rare, lending to differential diagnosis which includes bilateral macronodular adrenal disease (BMAD), synchronous adrenal adenomas and even adrenocortical carcinoma. The treatment consists of unilateral adrenalectomy, followed by contralateral adrenalectomy, if warranted by persistent significant CS.Aim: To present a case highlighting unilateral adrenalectomy...